schizophrenia
Conditions
Interventions
Schizophrenia oxytocin intervention group:Oxytocin intervention
Schizophrenia placebo intervention group:normal saline
Clinical high-risk population oxytocin intervention group:Oxytocin intervention
Clinical high-risk group placebo intervention group:normal saline
Healthy control oxytocin intervention group :Oxytocin intervention
Healthy control placebo intervention group :normal saline
Sponsors
First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Patient group: 1. Comply with DSM-5 clinical diagnostic criteria for schizophrenia; 2. Age 15-40 years; 3. Gender is not limited; 4. Han nationality; 5. Right handed; 6. At least two doctors at or above the level of attending should make diagnosis according to SCID-5 and meet DSM-5 diagnostic criteria for schizophrenia; 7. The patient and his/her family/guardian agreed to participate in the study and signed the informed consent. High risk group: 1. It is confirmed that it meets the diagnostic criteria of prodromal syndrome and has not received drug treatment through stereotyped interview of psychiatric risk syndrome; 2. The rest are the same as the patient group; Healthy control group: 1. No history of mental illness or family history of mental illness; 2. Age 15-40 years; 3. Gender is not limited; 4. Han nationality; 5. Right handed.
Exclusion criteria
Exclusion criteria: Patient group: 1. DSM-5 diagnosed as schizophrenic affective disorder, attention deficit and hyperactivity disorder, substance abuse induced mental disorder, mood disorder, mental retardation, generalized developmental disorder, delirium, dementia, memory disorder or other cognitive disorders; 2. Women are pregnant or lactating or have a pregnancy plan in the next six months; Suffering from severe unstable somatic diseases; 3. Color blindness, glaucoma or other eye diseases; 4. Persons with epilepsy history; 5. There are serious suicide attempts or serious excitement; 6. Those who cannot accurately understand the contents of various mental health assessment scales or complete computer operation, or have no guardians. High risk group: 1. DSM-5 patients diagnosed as schizophrenia, the rest are the same as the patient group. Healthy control group: 1. Have material dependence, or take drugs that may affect mental and cognitive functions, or have received antipsychotic treatment; 2. Suffering from nervous system diseases such as brain organic diseases, or other serious physical diseases; 3. Women are pregnant or lactating or have a pregnancy plan in the next six months; 4. Perceptual development disorder, color blindness, or other eye diseases that affect vision.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yoni task;Chinese version of the Movie for the Assessment of Social Cognition(MASC-C);VR task; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive and negative symptom scale(PANSS);Clinical global impressions scale(CGI);Electroencephalogram(EEG);Multimodal NMR data;MATRICS Consensus Cognitive Battery(MCCB);Social support rating scale(SSS);Revised adult attachment scale(AAS); | — |
Countries
China
Contacts
Public ContactWang xiao
Shanxi Medical University
Outcome results
None listed