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Effect of mechanical ventilation parameter adjustment under the guidance of esophageal pressure on reducing ventilator-associated lung injury in interstitial lung disease

Effect of mechanical ventilation parameter adjustment under the guidance of esophageal pressure on reducing ventilator-associated lung injury in interstitial lung disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200058722
Enrollment
Unknown
Registered
2022-04-15
Start date
2022-04-15
Completion date
Unknown
Last updated
2024-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

interstitial lung disease

Interventions

experimental group :Placement of esophageal pressure monitoring pipes ( including gastric function ) and adjustment of ventilator parameters under the guidance of esophageal pressure
control group:Place gastric tube only ( not having the function of monitoring esophageal pressure ), not monitoring esophageal pressure of patients

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Comply with the diagnosis of ILD in the 2018 version of ATS/ERS/JRS/ALAT official guide; 2. Mechanical ventilation is less than 48 hours; 3. Age>18 years.

Exclusion criteria

Exclusion criteria: 1. The patient has suffered from barotrauma (including pneumothorax, subcutaneous emphysema, mediastinal emphysema) when entering the ICU; 2. Pregnancy; 3. Near death state; 4. Other situations that are not suitable for placing esophageal pressure.

Design outcomes

Primary

MeasureTime frame
barotrauma;—

Secondary

MeasureTime frame
length of mechanical ventilation;length of ICU stay;ICU mortality;C3a;MIP- 2;IL-1;IL-6;TNF-a;—

Countries

China

Contacts

Public ContactZongan Liang

West China Hospital of Sichuan University

liangza@mcwcums.com+86 18980601259

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026