Major depressive disorder
Conditions
Interventions
Depression:Sertraline tablet or Duloxetine enteric-coated capsules
Normal control group:No
Sponsors
University City Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of depressive disorder group: 1. Chinese Han patients who meet DSM-5 diagnostic criteria for major depressive disorder; 2. Age 13-55 (including the threshold), gender unlimited, right handedness; 3. Children's Depression Scale (revised version) = 40 points (age<18 years) or Hamilton Depression Scale score = 17 points (age = 18 years) 4. Patients with hypomania symptom checklist (HCL-32) = 13 points to exclude bipolar disorder 5. No psychotropic drugs were used for 3 months before enrollment, and no antidepressant treatment was given for 2 weeks before enrollment; 6. The patient and/or the legal guardian voluntarily participated in the study, understood and signed the written informed consent. Inclusion criteria of healthy control group: 1. No mental illness in the past and at present; 2. 13-55 years old, Han nationality, primary school education or above; 3. The patient and/or the legal guardian voluntarily participated in the study, understood and signed the written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for depressive disorder group: 1. Patients who previously or currently meet the diagnosis below DSM-5: organic mental disorder, schizophrenia, schizoaffective disorder, bipolar affective disorder, mental retardation, dementia, other cognitive disorders, alcohol and drug dependence, personality disorder, etc; 2. Depression secondary to other mental or physical diseases; 3. Patients with serious or unstable somatic diseases; 4. Patients with epilepsy or other organic brain diseases; 5. Have a history of allergy to antidepressants in the past; 6. Women who are breast-feeding, pregnant or are likely to become pregnant during the trial; Male with fertility requirements within 1 year; 7. At present, there are contraindications to magnetic resonance, such as newly implanted heart stents, metal dentures, etc. Exclusion criteria for healthy control group: 1. Patients with severe or unstable somatic diseases; 2. Past or current organic brain diseases; 3. Two lineages and three generations have a family history of mental illness; 4. Women who are breast-feeding, pregnant or are likely to become pregnant during the trial; Male with fertility requirements within 1 year; 5. At present, there are contraindications to magnetic resonance, such as newly implanted cardiac stents, metal dentures, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale,HAMD;Hamilton Anxiety Scale,HAMA;Depression Scale for Children (Revised);Nine-item Patient Health Questionnaire,PHQ-9;Gene DNA sequences;DNA methylation level;RNA expression level;Brain magnetic resonance;Event-related potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| Udvalg for Kliniske Undersogelser;Gross Rating Scale;Social Work Deficiency Screening Scale; | — |
Countries
China
Contacts
Public ContactKuang Li
University City Hospital of Chongqing Medical University
Outcome results
None listed