protective lung ventilation
Conditions
Interventions
The control group:Set tidal volume to 10 ml/kg, inhaled oxygen concentration (FiO2) 100% during anesthesia induction and double lung ventilation, without end-expiratory positive pressure (PEEP)
test group 1:The tidal volume is set to 6~8ml/kg, the positive pressure at the end of expiratory breath (PEEP) is 3 to 5 cmH2O, and the inhaled gas oxygen concentration (FiO2) during anesthesia induct
test group 2:The tidal volume is set to 6~8ml/kg, the positive end-expiratory pressure (PEEP) is 3~5cmH2O, and the inhalation gas oxygen concentration (FiO2) during anesthesia induction and double lun
test group 3:The tidal volume is set to 6 to 8 ml/kg, the positive pressure at the end of breath (PEEP) is 3 to 5 cmH2O, and the inhaled gas oxygen concentration (FiO2) during anesthesia induction and
Sponsors
The Third Affiliated Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I or II; 2. Aged 18-85; 3.BMI 18-28 kg/m2; 4. No history of anemia and hypoproteinemia; 5. No history of chronic pain, central nervous and psychological diseases, antidepressants and sedatives, Parkinson's disease and epilepsy; 6. No history of hypoxemia, chronic obstructive pulmonary disease (COPD), other chronic pulmonary diseases and asthma before operation; 7. No obvious organic diseases such as brain, heart, lung, liver and kidney.
Exclusion criteria
Exclusion criteria: 1. preoperative MMSE score 4h, bleeding volume > 800ml; 11. The tourniquet has been used for more than 1.5 hours; 12. Those who do not agree to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, respiratory rate, blood oxygen saturation;PaO2, PaCO2, SaO2, Lac and calculated PaO2/FiO2 and intrapulmonary shunt rate Qs/Qt, alveolar artery oxygen partial pressure difference (PA-aDO2);Tidal volume (VT), lung compliance (Cdyn), peak airway pressure (PEAK), mean airway pressure (Pmean), plateau pressure (PLAT), airway resistance (Raw);Inflammatory indicators of the blood;The patient's mental state was assessed by MMSE score before surgery, and the postoperative cognitive function on the 1st and 3rd day after surgery was followed up to assess the cognitive function on the 1st and 3rd days after surgery;Record the time of tourniquet use, surgery time, anesthesia time, in and out, and underlying disease.; | — |
Countries
China
Contacts
Public ContactWang Qiujun
The Third Affiliated Hospital of Hebei Medical University
Outcome results
None listed