Postoperative delirium
Conditions
Interventions
HS group:Patients in the HS group are pre-injected with 4 mL/kg hypertonic saline.
NS group:Patients in the NS group are pre-injected with 4 mL/kg isotonic saline
Sponsors
The Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Shoulder arthroscopy is planned, the American Society of Anesthesiologists physical status I-III, aged 18 to 85 years, the anesthesia is general anesthesia.
Exclusion criteria
Exclusion criteria: 1. History of central nervous system (transient ischemic attack, stroke, hemorrhage, syncope, chronic headache, cervical disc herniation, spinal cord injury, orthostatic hypotension); 2. Electrolyte disorder; 3. MMSE score < 24 or a history of dementia, preoperative delirium, neurological or psychiatric disorders due to various causes; 4. Currently using sedatives or antidepressants; 5. Patients with infection or chronic inflammation who have recently taken anti-inflammatory drugs; 6. Do not agree to complete the experimental procedure; 7. Language impairment, hearing impairment or visual impairment, illiteracy; 8. Alcohol or drug dependence; 9. Allergies to pregnancy and narcotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neutrophil activation marker and count;S-100ß protein;Interleukin-6;Interleukin-6;tumor necrosis factor-a;cerebral oxygen saturation; | — |
Countries
China
Contacts
Public ContactQiujun Wang
The Third Hospital of Hebei Medical University
Outcome results
None listed