Lung injury
Conditions
Interventions
Traditional ventilation group:Conventional tidal volume ventilation
Lung protective ventilation group:Low tidal volume6ml/kg
Lung protective ventilation group:Positive end expiratory pressure5 cmH2O
Lung protective ventilation group:intermittent lung recruitment
Sponsors
The Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
1 Months to 6 Months
Inclusion criteria
Inclusion criteria: 1. Regardless of sex, age from 1 month to 6 months; 2. ASA grade I-II; 3. Elective laparoscopic surgery; 4. After fully explaining the contents of the clinical trial, the family members of the patients voluntarily tested and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with poor pulmonary ventilation; 2. Patients known to be allergic to narcotic drugs such as ropivacaine and cisatracurium; 3. Patients with asthma, epilepsy and cardiac insufficiency before operation; 4. Patients with abnormal liver and kidney function; 5. Patients judged to be family members who lack the ability of consent; 6. Patients with potential non-injury in basic diseases before operation. Such as severe infection, sepsis, patients with reflux aspiration, etc. 7. Patients with postoperative ICU support treatment with tube; 8. Patients with postoperative ventilation difficulties in the ward and need ventilator support treatment; 9. Patients with serious adverse events, according to the doctor's judgment, the trial should be stopped; 10. Sollow up shedding cases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications;Intraoperative respiratory parameters;Arterial blood gas parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital stay;C-reactive protein concentration;Body temperature 24 hours after operation;Extubation time;Postoperative PACU residence time; | — |
Countries
China
Contacts
Public ContactQi Chen
The Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed