gastric cancer
Conditions
Interventions
Case series:SOx
Case series:XELOX
Sponsors
The First Affiliated Hospital of Naval Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Histologically confirmed as gastric adenocarcinoma or gastric esophageal junction adenocarcinoma (excluding Siewert I type), according to AJCC version 7 gastric cancer staging, the clinical disease stage of the enrolled patients is cT3/T4aN+M0, or cT4bN -/+M0; 2. It is judged that radical resection is possible; 3. No initial treatment (radiotherapy or chemotherapy); 4. 18 = 75; 5. ECOG score = 2; 6. Estimated life span>3 months; 7. Laboratory examination can tolerate surgery and chemotherapy; 8. Willing to abide by the program during the study; 9. Before enrollment, the patient can obtain written informed consent, and the patient should understand that he/she has the right to withdraw from the experiment at any time without affecting the follow-up treatment; 10. Agree to provide hematological and histological specimens.
Exclusion criteria
Exclusion criteria: 1. Those who have received chemotherapy, radiotherapy or immunotherapy before participating in this study; 2. Not enough tumor organizers can be obtained through biopsy; 3. Those who cannot complete the test due to physical conditions; 1) Heart disease, unstable angina, myocardial infarction within 1 year 2) Imaging and clinical symptoms suggest intestinal obstruction 3) Bleeding symptoms with significant clinical significance or a clear tendency to bleed within 3 months 4) Arteriovenous thrombosis events occurred within 6 months, such as cerebrovascular accident (including temporary ischemic attack, cerebral hemorrhage, cerebral infarction), deep vein thrombosis, pulmonary embolism, etc 4. Patients with other malignant tumors within 5 years; 5. Have mental illness or other serious cardiovascular diseases; 6. Those who have no independent decision or refuse to participate in the test; 7. The exclusion conditions that cannot be classified into the above categories, or the researcher thinks that it is not suitable to participate in the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mpr;os;AEs; | — |
Countries
China
Contacts
Public ContactYin Kai
The First Affiliated Hospital of Naval Medical University
Outcome results
None listed