The study on the mechanism of arachidonic acid metabolic disorder affecting sperm quality

Study on mechanism and clinical intervention measures of arachidonic acid metabolic disorder affecting sperm motility in obese and infertile men

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200058629

Enrollment

Unknown

Registered

2022-04-12

Start date

2022-05-01

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility

Interventions

Obesity group 1: reduce weight

Obesity group 2:reduce weight + glycyrrhizic acid

control group:Non intervention

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Aged 25-35 years; 2. BMI greater than 30kg / m2 and BMI greater than 17.5 and less than 24kg / m2; 3. Healthy men preparing for pre pregnancy examination; 4. Forbid entry for 2-7 days.

Exclusion criteria

Exclusion criteria: 1. Inflammatory lesions of reproductive system; 2. Varicocele; 3. Genetic diseases such as chromosome abnormalities; 4. Cryptorchidism; 5. hypertension, diabetes and other systemic diseases.

Design outcomes

Primary

Measure	Time frame
Arachidonic acid;5-LOH;COX;LTB4;PG;sperm quality;DFI;Intestinal Microecology;Sperm DNA methylation;	—

Countries

china

Contacts

Public ContactLiu Yongjie

Yinchuan Maternity and Child Health Care Hospital

lyj1722006@126.com+86 13469510369

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026