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A prospective single-arm Phase II study of induction chemotherapy combined with functional preservation surgery and postoperative radiotherapy for locally advanced head and neck squamous cell carcinoma

A prospective single-arm Phase II study of induction chemotherapy combined with functional preservation surgery and postoperative radiotherapy for locally advanced head and neck squamous cell carcinoma

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200058625
Enrollment
Unknown
Registered
2022-04-12
Start date
2022-04-01
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

head and neck cancer

Interventions

test:induction chemotherapy(PR)+surgery +radiotherapy/CCRT

Sponsors

National Cancer Center, Cancer Hospital & Institute, Chinese Academy of Medicine Sciences (CAMS) & Peking Union Medical College (PUMC)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age 18-75 years; 2. ECOG score 0-2; 3. No anti-tumor treatment has been performed in the past, and histology has confirmed squamous cell carcinoma (nasal cavity, paranasal sinus, oral cavity, hypopharynx); 4. The primary tumor is adjacent to important organs, and the conventional surgical scope requires the removal of organs (maxillectomy, mandibular segmental resection, total laryngectomy), but there is no obvious clinical evidence indicating bone invasion. The clinical lymph node staging was N1-2.

Exclusion criteria

Exclusion criteria: 1. Assess suspected distant metastasis before treatment; 2. The pathology is non squamous carcinoma or the primary lesion pathology contains non squamous cell components.

Design outcomes

Primary

MeasureTime frame
Organ retention rate;—

Countries

china

Contacts

Public ContactJie Liu

National Cancer Center, Cancer Hospital & Institute, Chinese Academy of Medicine Sciences (CAMS) & Peking Union Medical College (PUMC)

liuj@cicams.ac.cn+86 13910217810

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026