Sepsis associated encephalopathy
Conditions
Interventions
Control group:None
The routine treatment group for sepsis associated encephalopathy:Routine treatment
Sepsis associated encephalopathy Glutathione intervention group:Routine treatment and Glutathione
Sponsors
Xuzhou Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 16 Years
Inclusion criteria
Inclusion criteria: 1. Children aged from 28 days to 16 years; 2. Presenting with symptoms of infection, sequential organ failure score>=2; 3. Children with acute disturbance of consciousness, such as coma, delirium, convulsion and abnormal agitation, Pediatric Glasgow Coma Scale Score <=12.
Exclusion criteria
Exclusion criteria: 1. Underlying neurological disorders; 2. Intracranial infection, intracranial hemorrhage and organic pathological changes; 3. Other system function failure secondary to the neurological dysfunction, such as hepatic encephalopathy, renal encephalopathy and so on; 4. Congenital metabolic disorder, brain damage caused by poisoning, etc.; 5. Allergic to Glutathione.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Days of coma; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate;Central specific protein;Glial fibrillary acidic protein;Superoxide dismutase;Glutathione peroxidase-4;Pediatric Glasgow Coma Scale; | — |
Countries
China
Contacts
Public ContactWang Haosen
Xuzhou Children's Hospital
Outcome results
None listed