obstructive sleep apnea hypopnea syndrome (OSAHS)
Conditions
Interventions
Case group:None
Healthy control group:None
Sponsors
The Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
22 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for OSAHS patients: (1) All patients met the diagnostic criteria of moderate and severe OSAHS and underwent overnight polysomnography (PSG) monitoring (>7h) after respiratory disorder index (AHI) [AHI=(number of apnea + number of hypopnea)/ sleep time (h)x100%]>15 times/h; The condition is relatively stable; (2) Aged 22 to 60 years, no gende limit; (3) No treatment such as positive pressure ventilation and surgery; (4) Right-handedness (handedness was judged according to the criteria of Neurology Department of the First Hospital of Beijing Medical University); (5) Signed informed consent and accepted the experiment voluntarily. 2. Inclusion criteria of healthy volunteers: (1) No OSA or other sleep disorders were confirmed by polysomnographic monitoring; (2) No gender limit, aged 22-60 years; (3) Right-handed; (4) Signed informed consent and accepted the experiment voluntarily.
Exclusion criteria
Exclusion criteria: 1. Abuse illegal drugs or alcohol; 2. Brain MRI found lesions (such as cerebral infarction, cyst, tumor, etc.); 3. There are MRI contraindications (such as claustrophobia, plate implantation, etc.); 4. A history of neurological or psychiatric disorders (e.g. neurodegenerative diseases, epilepsy, brain trauma, depression, peripheral diseases, etc.); 5. Other sleep disorders (such as restless leg syndrome, hypersomnia, primary insomnia and narcolepsy, etc.); 6. History of cardiovascular disease, hypertension and diabetes; 7. Patients with cerebral vascular pathological variation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Epworth Sleepiness Score;Low-frequency amplitude ratio;Local consistency;Functional connection;Magnetic resonance spectrum;Arterial spin labeling; | — |
Countries
China
Contacts
Public ContactChen Junqi
The Third Affiliated Hospital of Southern Medical University
Outcome results
None listed