treatment-resistent depression (TRD)
Conditions
Interventions
Control group:antidepressants treatment
Experimental group:antidepressant therapy and dynamic interpersonal therapy
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Meet the DSM-5 diagnosis of major depressive disorder; 2. At least 2 or more antidepressants with different mechanisms of action were ineffective in adequate doses and treatment courses (continuous treatment >=6 weeks) (17 items of Hamilton depression scale, namely 17-HAMD reduction rate =17, 14 items of HAMA score <=21, and no psychotic symptoms were associated; 4. Education level above junior high school; 5. Aged 18-55 years, no gender limit; 6. No systematic psychological treatment for nearly 6 months; 7. Have sufficient visual and auditory skills to perform the necessary examinations; 8. Willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Serious organic disease; 2. History of craniocerebral trauma or disturbance of consciousness; 3. Brain MRI examination revealed pathological changes; 4. Comorbid with other mental diseases; 5. History of past or current (mild) manic episodes; 6. History of dependence on psychoactive substances; 7. Pregnant and lactating patients; 8. Serious suicide attempts.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale for Depression;Brief Patient Health Questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adult Attachment Scale;Extrinsic Affect Simon Task; | — |
Countries
China
Contacts
Public ContactQiu Jianyin
Shanghai Mental Health Center
Outcome results
None listed