depression
Conditions
Interventions
Depression group:Antidepressants (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, esitalopram, venlafaxine)
Healthy control group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for patients with depression: (1) Meet the diagnostic criteria for major depressive disorder in DSM-?; (2) Demographic information criteria: aged 18-60 years, Han nationality, right-handed; (3) First episode without prior use of any antidepressants, antipsychotics, or sedative sleeping pills; (4) Clinical treatment is consistent with the sequential treatment plan of this study. 2. Inclusion criteria of healthy volunteers: (1) Demographic information criteria: aged 18-60 years, Han nationality, right-handed; (2) Intelligence level: intelligence of Wechsler >= 90, education level: graduation from primary school or education age >= 6 years; (3) Complete social function (normal work, school, not illness), with full behavior and responsibility ability.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for patients with depression: (1) Patients with serious physical or neurological diseases; (2) Patients with metal objects (such as metal dentures, cardiac pacemakers, etc.) in the body affecting the MRI examination; (3) Patients with color blindness, etc. can not effectively complete the examination. 2. Exclusion criteria for healthy subjects: (1) Disease history: subjects diagnosed with DSM-? axis ? and axis ?, with serious organic diseases of body and brain; (2) Drug treatment history: used to take psychotropic drugs; (3) Family history: a family history of mental illness in two or three generations; (4) Subjects with metal objects (such as metal dentures, cardiac pacemakers, etc.) in the body affecting the MRI examination; (5) Colorblind subjects who cannot effectively complete the assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cranial MRI;Hamilton Depression Questionnaire -17;Beck Depression Inventory-21;Environmental Factors Assessment Scale;Cognitive symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Young's Mania Rating Scale;Hamilton Anxiety Scale;Beck Depression Inventory;Childhood Trauma Questionnaire -28;Ottawa Self-injury Scale;Temporal Experience of Pleasure Scale;Pittsburgh Sleep Quality Index Scale;Morningness-Eveningness Questionaire;Epworth Sleepiness Scale;Social Support Rating Scale;Eysenck Personality Questionnaire;Life Event Scale; | — |
Countries
China
Contacts
Public ContactYang Xiao
West China Hospital of Sichuan University
Outcome results
None listed