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The role and mechanism of intestinal microbiota-associated metabolites putrescine and taurine in the development of gestational diabetes mellitus via the gut-adipose tissue axis

The role and mechanism of intestinal microbiota-associated metabolites putrescine and taurine in the development of gestational diabetes mellitus via the gut-adipose tissue axis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200058507
Enrollment
Unknown
Registered
2022-04-10
Start date
2022-04-01
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational Diabetes Mellitus (GDM)

Interventions

GDM group:none
Control group:none

Sponsors

Beijing Obstetrics and Gynecology Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Single pregnant women who plan to register in our hospital, have regular birth check-up and give birth; 2. Aged 18-40 years; 3. 8-12 weeks of pregnancy.

Exclusion criteria

Exclusion criteria: 1. Patients with previous hypertension, hyperlipidemia, diabetes, hepatitis, nephritis, digestive tract diseases, infectious diseases, cardiovascular diseases and endocrine diseases; 2. Patients who stay in bed and preserve fetuses; 3. Patients who take drugs that may affect intestinal microbiota.

Design outcomes

Primary

MeasureTime frame
serum putrescine levels;serum taurine;fasting blood glucose;insulin resistance index;inflamatory factor;glucose tolerance test;insulin tolerance test;tissue pathology;—

Countries

China

Contacts

Public ContactLi Guanghui

Beijing Obstetrics and Gynecology Hospital, Capital Medical University

liguanghui@ccmu.edu.cn+86 13124728821

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026