perioperative neurocognitive disorders
Conditions
Interventions
Group 1:General anesthesia, pre-debilitating: 0.9% sodium chloride
Group 2:General anesthesia, pre-debilitating: dexmedetomidine
Group 3:General anesthesia, debilitating phase: 0.9% sodium chloride
Group 4:General anesthesia, debilitating phase: dexmedetomidine
Group 5:Non-general anesthesia, pre-debilitating: 0.9% sodium chloride
Group 6: Non-general anesthesia, pre-debilitating: dexmedetomidine
Group 7:Non-general anesthesia, debilitating phase: 0.9% sodium chloride
Group 8: Non-general anesthesia, debilitating phase: dexmedetomidine
Sponsors
Wuhan Fourth Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 110 Years
Inclusion criteria
Inclusion criteria: 1. Patients older than or equal to 60 years old; 2. Patients with a score of 1 or more on the Frail scale; 3. Patients who are informed and agree to the content of this study.
Exclusion criteria
Exclusion criteria: 1. Patients with mental disorders or communication disorders; 2. Patients allergic to dexmedetomidine and its components; 3. Patients with serious dysfunction of vital organs and unable to tolerate surgery; 4. Patients undergoing emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarkers for brain injury;Incidence of perioperative neurocognitive disorders;Neuropsychological test; | — |
Countries
China
Contacts
Public ContactXiaohong Peng
Jianghan University
Outcome results
None listed