Bradycardia induced by neostigmine in surgical patients
Conditions
Interventions
Group 1 :Atropine 0.016 mg/kg for the prevention and treatment of neostigmine bradycardia
Group 2:Glonium bromide 0.01 mg/kg for the prevention and treatment of neostigmine bradycardia
Group 3:Glonium bromide 0.008 mg/kg for the prevention and treatment of neostigmine bradycardia
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. For patients undergoing elective general anesthesia for non-cardiac surgery, the estimated operation time is 1.5-3 hours; 2. Use neostigmine to antagonize non-depolarizing muscle relaxants after surgery; 3. Age 18-65 years, male or female; 4. ASA grade I-II; 5. Patients with a BMI value of 18.5-23.9 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Severe heart and lung, liver and kidney, central nervous system and peripheral nervous system diseases; 2. Those with a history of allergy to anticholinergic drugs; 3. Pregnant and lactating women; 4. Those who are using anticholinergic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of difference between heart rate and baseline heart rate 15 minutes after experimental drug administration ;heart rate variability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured heart rate per minute within 15 min after medication administration;The difference between measured heart rate and baseline heart rate;Frequency and dose of atropine;Adverse events were followed up 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactTian Dandan
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed