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Study on multimodal imaging for regulating neuroplasticity of patients with subjective cognitive decline treated by acupuncture: a randomized controlled trial

Acupuncture treatment patients with subjective cognitive decline by regulating white matter fibers and functional connection in medial prefrontal cortex: a multimodal imaging study

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200058485
Enrollment
Unknown
Registered
2022-04-09
Start date
2022-04-11
Completion date
Unknown
Last updated
2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

subjective cognitive decline

Interventions

Group 1:Acupuncture Baihui, Shenting, Fengchi, Tanzhong, Zhongwan, Qi Sea, Neiguan, Zusanli, Blood Sea
Group 2:Paste the disposable sterile foam pad on the non-acupoint, and use a 0.35 x 25 mm disposable sterile flat-tip acupuncture needle to pierce the foam pad, touch it lightly but not pierce the ski

Sponsors

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age 55-75 years, male or female, right-handed; 2. Chief complaint of cognitive decline, or cognitive decline reported by insiders; 3. The overall cognitive examination is normal: Montreal cognitive assessment scale Chinese version (MOCA): > 19 (primary school and below), > 22 (secondary school), > 24 (college); Mini-Mental State Examination (MMSE) > 24 (high school education), > 20 (primary), > 17 (illiterate); 4. Education level above elementary school, no visual, auditory or intellectual impairment, language barrier, can answer and fill in the questionnaire smoothly; 5. Not taking psychotropic drugs that affect cognition before and during the entire treatment process; 6. The patient himself and (or) his family members signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Other neurological diseases that can lead to cognitive decline other than suspected early Alzheimer's disease: such as Parkinson's disease, vascular dementia, Huntington's disease, positive pressure hydrocephalus, and brain tumors; 2. Other systemic diseases that can cause cognitive decline: such as Hashimoto's encephalopathy, metabolic encephalopathy and anemia; 3. There are pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments in the body; foreign objects in the eyes, skin or body; 4. Have a history of severe depression, bipolar disorder, schizophrenia and other mental illnesses; 5. A history of alcohol or drug abuse/addiction within the past two years; 6. Any other systemic diseases or uncertain conditions make it impossible to complete the project; 7. Received acupuncture treatment in the past 1 month.

Design outcomes

Primary

MeasureTime frame
Brain functional magnetic resonance data;cognitive evaluation outcomes;Safety index;Adverse Events;

Countries

China

Contacts

Public ContactYan Chaoqun

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

yanchaoqun857@126.com+86 18810862051

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026