Metabolic diseases, including type 2 diabetes mellitus, hypertension, lipid metabolism disorders and hyperuricemia
Conditions
Interventions
Experimental group:Lifestyle flexible intervention
Control group:Continuous canteen diet intervention + exercise prescription suggestions
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Employees who belong to the three Guangxi China Resources Cement Companies covered by this study; 2. Body mass index (BMI) >= 24.0 Kg/m2; 3. Meet any of the following clinical conditions: (1) Diagnosed with type 2 diabetes, or glycosylated hemoglobin (HbA1c) >= 6.5% in the latest annual physical examination; (2) Hypertension was diagnosed, or the latest annual physical examination revealed abnormal blood pressure and the follow-up monitoring satisfied the resting blood pressure >= 140/90 mmHg for 3 times on different days; (3) Diagnosed with lipid metabolism disorder, or triglyceride (TG) >= 2.26 mmol/L and/or low-density lipoprotein cholesterol (LDL-c) >= 3.37 mmol/L in the latest annual physical examination; (4) Diagnosed with hyperuricemia or gout, or the latest annual physical examination showed abnormal uric acid and the follow-up reexamination met the blood uric acid >= 420 umol/L twice on different days; 4. Estimated glomerular filtration rate (eGFR) >= 60, alanine aminotransferase (ALT) < 120 U/L; 5. No acute metabolic disorder state.
Exclusion criteria
Exclusion criteria: 1. Other types of diabetes other than type 2 diabetes: including type 1 diabetes, pancreatic disease, diabetes caused by drugs or chemical agents; 2. Secondary hypertension: including endocrine hypertension, renal hypertension, etc.; 3. Acute complications of uncorrected metabolic disease (eg, diabetic ketoacidosis (DKA), hyperosmolar hyperglycemic state (HHS), lactic acidosis, malignant hypertension, hypertensive encephalopathy, hypertensive crisis, acute pancreatitis (considered associated with hypertriglyceridemia), severe gouty arthritis attacks); 4. Positive exercise treadmill test; 5. eGFR = 120 U/L; 6. History of kidney transplantation; 7. Cardiac function class (NYHA) III-VI; 8. Stroke, myocardial infarction in the past 12 months; 9. A history of severe mental disorders; 10. Hemoglobinopathies or uncorrected severe anemia; 11. Unexplained hypoglycemia with disturbance of consciousness occurred in the past 6 months; 12. No smartphone or no access to mobile software; 13. Potential failure to comply with protocol requirements: including communication barriers, uncooperative attitudes, inability to follow up and inability to complete the study; 14. There are conditions that may endanger the safety of patients or fail to participate in the research: including medical, psychological, geographical factors, etc.; 15. Participated in a clinical trial within 8 weeks before randomization, could not complete the 12-month study follow-up, and needed elective treatment such as surgery within 12 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body mass index and body fat percentage;Glycosylated hemoglobin, HbA1c;Blood pressure;Triglycerides or low density lipoprotein cholesterol;Blood uric acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise self-efficacy;Research direct cost;Long term cost effectiveness; | — |
Countries
China
Contacts
Public ContactAng Li
Peking University First Hospital
Outcome results
None listed