chronic myeloid leukemia
Conditions
Interventions
None listed
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 14 years, male or female; 2. For Ph+CML-CP patients, one of the following conditions should be met: (1) Newly diagnosed patients with CML-CP; (2) CML-CP patients who did not respond optimally to TKIs (BCR-ABLIS > 10% at 3 months or BCR-ABLIS > 1% at 6 months or BCR-ABLIS > 0.1% at 12 months and BCR-ablis > 0.01% at 24 months) or were intolerant to some TKI. Definition of diagnosis: Bone marrow cytogenetics Ph chromosome t(9;22) Positive, BCR-ABL fusion gene was detected by FISH, or BCR-ABL fusion gene was detected by Q-PCR ( > 10%); 3. No history of hematopoietic stem cell transplantation; 4. The pregnancy test of fertile female patients was negative (within 7 days before enrollment); 5. There is a need for drug withdrawal, and informed consent must be signed voluntarily before screening.
Exclusion criteria
Exclusion criteria: 1. T315I mutation is known to exist; 2. Received stem cell transplantation before joining the group; 3. Suffering from other malignant tumors and requiring active intervention; 4. Those who are unable to comply with the program steps or follow up on time; 5. The physical fitness score (EcoGPS) of the Eastern Cancer Collaborative Group is >= 3; 6. Other situations that the researcher thinks are not suitable for selection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| treatment free remission rate of 2 years;deep molecular response of 12 months; | — |
Countries
China
Contacts
Public ContactJianyu Weng
Guangdong Provincial People's Hospital
Outcome results
None listed