Corona Virus Disease 2019, COVID-19
Conditions
Interventions
Group 1 :Standard COVID-19 Treatment Protocol
Group 2:Combined with Paxlovid
Sponsors
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age above 18 years and below 90 years; 2. Hospitalized patients with mild or common type of SARS-CoV-2 confirmed by PCR, whose last nucleic acid sampling time was within 48 hours before inclusion; 3. Within 48 hours after admission; 4. PCRCt value of viral nucleic acid in nasal/pharyngeal swabs = 2 points or charson score >= 2 points due to other non-COVID-19 causes; 6. The patient was fully informed and agreed to participate in the study and expected to complete the treatment and examination related to the study.
Exclusion criteria
Exclusion criteria: 1. A history of COVID-19 infection; 2. A known history of active liver disease (other than non-alcoholic hepatic steatosis), including chronic or active hepatitis B or C infection, primary biliary cirrhosis, Child-PughB or C grade, or acute liver failure; 3. Receiving dialysis or known moderate to severe renal impairment (i.e., EGFR = 2.5 times the upper limit of normal; (2) Total bilirubin >= 2 times the normal high limit; (3) Absolute count of neutrophils < 1000 /mm^3; glomerular filtration rate < 45 ml/min /1.73m2 within 3 months; 10. Breastfeeding or pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inpatient mortality;Conversion rate of severe COVID-19 within 14 days;Acute exacerbation rate of chronic underlying diseases within 14 days;Nucleic acid negative rate within 7 days;Nucleic acid negative conversion rate within 14 days;Nucleic acid negative time;Total in-hospital days;Duration of stay in ICU;Percentage requiring organ function support within 28 days; | — |
Countries
China
Contacts
Public ContactDechang Chen
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed