Peripheral sensitization of tension-type headache based on magnetic resonance imaging

Sensitization mechanism of Shaogan Granule on tension-type headache based on ATP-P2X7 pathway

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200058447

Enrollment

Unknown

Registered

2022-04-09

Start date

2022-05-01

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tension-type headache

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of chronic TTH; 2. There were no contraindications of fMRI, such as no metal implants, no claustrophobia, no involuntary movement, etc; 3. No organic diseases of brain and normal functions of the heart, liver and kidney; 4. Informed consent.

Exclusion criteria

Exclusion criteria: 1. Persons younger than 18 years old or older than 65 years old, pregnant or lactating women,; 2. Cerebral arteriosclerosis and hypertension, headache caused by pericranial diseases, mixed headache, such as vascular headache; 3. People who are using opioid analgesics, antipsychotic drugs or ergotamine, alcoholics or other drugs abuse; 4. Patients with severe primary diseases such as heart, brain, liver, kidney and hematopoietic system, and mental illness.

Design outcomes

Primary

Measure	Time frame
Cervical muscle area;	—

Secondary

Measure	Time frame
Cranial vertebral angle;Neck disability index;Headache Impact Test (HIT-6);Information-memory-concentration test;	—

Countries

China

Contacts

Public ContactWu Hongyun

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

whylzhangonly@126.com+86 13853148590

Outcome results