Refractory esophageal stricture after esophageal atresia
Conditions
Interventions
Group A:Mitomycin combined with esophageal dilation in the treatment of esophageal stricture
Group B:Bleomycin combined with esophageal dilation in the treatment of esophageal stricture
Sponsors
Beijing Children's Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. The patient was diagnosed with postoperative esophageal stricture following esophageal atresia repair at Capital Medical University Affiliated Beijing Children's Hospital, based on clinical evaluation and imaging studies. 2. According to the ESPGHAN-ESGE guidelines, it was in line with the diagnosis of refractory esophageal stricture, that is, 5 times of routine esophageal dilation have been performed, and the interval between each dilation is not more than 4 weeks, and age-appropriate feeding has still not been obtained, and there is an indication for combined gastroscopic drug injection; 3. Signed informed consent before the examination, surgery Consent and off-label medication.
Exclusion criteria
Exclusion criteria: 1. Those who underwent esophageal surgery during the study period; 2. Those who had serious underlying diseases and who could not tolerate gastroscope; 3. Those who had severe complications after esophageal atresia; 4. Those who had poor compliance with treatment or clinical research; 5. Those who refused to participate in this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dysphagia score;Relative changes in the length of esophageal strictures;The relative change of lumen diameter of esophageal stricture;Use of anti-reflux medications;Number of esophageal dilations;Treatment costs; | — |
Countries
China
Contacts
Public ContactJinshi Huang
Beijing Children's Hospital, Capital Medical University
Outcome results
None listed