Cerebral small vessel disease
Conditions
Interventions
None listed
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Inpatients of Tongji Hospital; 2. Age > 18 years; 3. All patients underwent MRI (T1WI, T2WI, FLAIR) + DWI + SWI. Lesions on MRI can be inferred as "presumed cerebral small vascular origin"; 4. MRI of patients meet criteria I: The total WMH Fazekas score >= 3, or number of lacune >= 1; Or criteria II: Total WMH Fazekas score = 3; Or criterion III: or recent subcortical small infarctions appears on DWI; 5. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Significantly limited independent living ability, and unable to cooperate to complete the inspection; 2. Cerebral hemorrhage, subarachnoid hemorrhage, intracranial space-occupying lesions and other diseases at present; 3. Acute ischemic stroke with infarction diameter greater than 2cm, or severe stroke at baseline (NIHSS score = 15); 4. Severe depression and anxiety; 5. Serious mental disorders such as schizophrenia; 6. Other nonvascular diseases that cause leukoencephalopathy, including CO poisoning, multiple sclerosis and adrenoleukodystrophy; 7. Dementia or cognitive impairment caused by other non vascular causes (such as frontotemporal dementia, Alzheimer's disease, Lewy body dementia, prion protein disease, Parkinson's disease, autoimmune encephalitis, etc.); 8. Serious systemic diseases, such as serious liver and kidney diseases, respiratory diseases, cancer, and severe acute infection; 9. Subjects who can not cooperate with neuropsychological assessment and MRI examination due to obvious hearing or vision impairment, language disorder, claustrophobia, etc.; 10. The expected service life is less than 1 year; 11. Patients who could not be followed up during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demographic data;Past history and risk factors;Family history;Imaging data;Assessment of daily living ability;Overall Cognitive Test and Dementia Assessment;New stroke;New cardiovascular events;Subdomain Cognitive Test;General health assessment;Fatigue assessment; | — |
Countries
China
Contacts
Public ContactWenhao Zhu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed