Parkinson's disease
Conditions
Interventions
RIC group:Electronic tourniquets will be placed on both arms. Participants in the intervention group will inflate the cuff to 200 mmHg for 5 minutes after five cycles, and then deflate it for 5 minute
Control group(sham-RIC group):Electronic tourniquets will be placed on both arms. Participants in the intervention group will inflate the cuff to 60 mmHg for 5 minutes after five cycles, and then defl
Sponsors
Beijing Luhe Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Parkinson's disease patients diagnosed according to MDS clinical diagnostic criteria for Parkinson's disease; 2. Age 18-90 years old; 3. The patient's ESS score >=10; 4. The patient's vital signs were stable; 5. Written informed consent provided by the participant or legally authorized representative.
Exclusion criteria
Exclusion criteria: 1. Contraindication of ischemic conditioning (such as severe soft tissue injury, fracture and peripheral vascular disease of both upper limbs); 2. The patients' compliance is poor and follow-up cannot be completed.; 3. Life expectancy <=1 year; 4. Serious diseases such as lung, liver, and kidney are not controlled and stable; 5. Coagulation dysfunction or active bleeding; 6. Complicated with acute coronary syndrome or severe arrhythmia; 7. Pregnant or nursing patients; 8. Participating in another ongoing clinical trial within 30 days before the study is included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any serious RIC-related adverse events;Epworth sleepiness score (ESS);Pittsburgh sleep quality index, PSQI;Parkinson's Disease Sleep Scale (PDSS-2);Parkinson's Disease Questionnaire (PDQ-39); | — |
Countries
China
Contacts
Public ContactQiling Ji
Beijing Luhe Hospital, Capital Medical University
Outcome results
None listed