Subjective Cognitive Decline and Mild cognitive Impairment
Conditions
Interventions
SCD(1Hz):Transcutaneous vagus nerve stimulation(1Hz)
SCD(20Hz):Transcutaneous vagus nerve stimulation(20Hz)
SCD(stVNS):Sham transcutaneous vagus nerve stimulation
MCI(1Hz):Transcutaneous vagus nerve stimulation(1Hz)
MCI(20Hz):Transcutaneous vagus nerve stimulation(20Hz)
MCI (stVNS):Sham transcutaneous vagus nerve stimulation
HC(1Hz):Transcutaneous vagus nerve stimulation(1Hz)
HC(20Hz):Transcutaneous vagus nerve stimulation(20Hz)
HC(stVNS):Sham Transcutaneous vagus nerve stimulation
Sponsors
People's Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria: (1) Age 55-75 years old; (2) Han; (3) Right-handed; (4) Diseases that may cause dysfunction of the brain. 2. The criteria of SCD: (1) Self-experienced persistent decline in cognitive capacity in comparison with a previously normal status and unrelated to an acute event; (2) Normal age-, gender-, and education-adjusted performance on standardized cognitive tests, which are used to classify mild cognitive impairment (MCI) or prodromal AD. 3. The criteria of MCI: (1) Cognitive concern reflecting a change in cognition reported by patient or informant or clinician; (2) Objective evidence of Impairment in one or more cognitive domains, typically including memory; (3) Preservation of independence in functional abilities; (4) Not demented.
Exclusion criteria
Exclusion criteria: 1. Dementia; 2. Central nervous system diseases such as cerebral vascular disease, Parkinson's disease, encephalitis, epilepsy, tumor, and trauma; 3. Systemic diseases that can lead to cognitive impairment, such as hypothyroidism, VB12 or folate deficiency, neurosyphilis, HIV infection, severe anemia, hepatic encephalopathy, carbon monoxide poisoning, etc; 4. Previous history of psychosis; 5. Substance factors such as drug abuse; 6. Related risk factors such as history of hypertension, history of hyperlipidemia, history of diabetes, smoking and drinking history, etc; 7. Patients who had used other drugs that may cause changes in cognitive function or failure of important organs such as heart, brain, and kidney before inclusion; 8. Failing to cooperate in completing the corresponding assessment and inspection and quitting halfway; 9. Contraindications of magnetic resonance examination (such as metal dentures or other metal implants that cannot be removed, claustrophobia, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| resting-state brain functional MRI;Brain three-dimensional T1 weighted imaging;Diffusion tensor imaging;Arterial Spin Labeling; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum Mental State Examination;Montreal Cognitive Assessment;Auditory verbal learning test;Shape trails test;Animal fluency test;Boston Naming Test;Hamilton Depression Scale;Hamilton Anxiety Scale;Geriatric Depression Scale;Neuropsychiatric inventory;Functional activities questionnaire;Pittsburgh Sleep Quality Index;Rapid eye movement sleep behavior disorder screening questionnaire;Epworth Sleepiness Scale;Subjective Cognitive Decline Questionnaire; | — |
Countries
China
Contacts
Public ContactLingyan Liang
People's Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed