Peritoneal carcinoma
Conditions
Interventions
SVV group:Goal-directed fluid therapy guided by stroke volume variation
CVP group:Goal-directed fluid therapy guided by central venous pressure
Sponsors
Beijing Shijitan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The diagnosis was peritoneal carcinoma; 2. ASA 1-3, patients with cytoreductive surgery combined with peritoneal hyperthermia chemotherapy under general anesthesia; 3. Aged 18 to 65 years old; 4. The chemotherapy regimen was cisplatin 120mg+ mitomycin 20mg, lasting 1 hour; 5. Informed consent to this study.
Exclusion criteria
Exclusion criteria: 1. Coagulation dysfunction, arterial puncture, central venous catheterization contraindications; Radial artery puncture cannot be performed; 2. Patients who had myocardial infarctions within 3 months before surgery, or currently complicated with heart failure, severe valvular heart disease, arrhythmia; 3. Patients with severe renal insufficiency, creatinine 442ummol/l, or renal dialysis; 4. The Child-pugh rating is GRADE C.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| End-diastolic volume, EDV;Global end-diastolic volume index, GEDVI;Ejection fraction, EF;Stroke volume, SV; | — |
Secondary
| Measure | Time frame |
|---|---|
| TnI;BNP;Urine output;Postoperative exudate volume;Number of cardiac complications after operation;Cases of postoperative hypotension; | — |
Countries
China
Contacts
Public ContactYifan An
Beijing Shijitan Hospital, Capital Medical University
Outcome results
None listed