Rectal Cancer
Conditions
Interventions
uSPP group:Ultimate sphincter-preserving procedures
ELAPE group:Extralevator abdominoperineal excision
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old; 2. Pathologically confirmed adenocarcinoma of the rectum; 3. The lower edge of the tumor is <=5 cm from the anus; 4. Rectal MRI staging of cT1-2N1-2M0 or cT3N0-2M0 before radiotherapy; 5. 6-12 weeks after receiving long course neoadjuvant radiotherapy (50Gy/25f); 6. Understand the study protocol and volunteer to participate.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Combined with other primary tumors or with distant metastases; 3. ASA>=IV; 4. PS>2; 5. Pregnant or breastfeeding women; 6. Severe cardiopulmonary complications cannot tolerate surgery; 7. Continuous systemic steroid therapy for 1 month; 8. Contraindication to laparoscopic surgery or MRI; 9. Tumor invasion or suspected invasion of the vagina, prostate, sacrococcyx, and lateral pelvic wall (T4b); 10. Those who can only undergo non-anal preservation surgery after preoperative evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| socre of Quality of Life Questionaire - Cancer 30 (QLQ-C30); | — |
Secondary
| Measure | Time frame |
|---|---|
| score of Quality of Life Questionnaire - Colorectal 29 (QLQ-CR29);score of Low Anterior Resection Syndrome (LARS);Score of Wexner Incontinence Score (WIS);Score of International Prostate Symptom Scale (IPSS);Score of International Index of Erectile Function-5 (IIEF-5);Score of Female Sexual Function Index (FSFI);Health Economics indexes; | — |
Countries
China
Contacts
Public ContactLie Yang
West China Hospital of Sichuan University
Outcome results
None listed