Bullous Pemphigoid, BP
Conditions
Interventions
Experimental group:Dupilumab
Sponsors
Xijing Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, no gender restriction; 2. According to "Expert Recommendations for the Diagnosis and Treatment of Bullous Pemphigoid" (Autoimmune Disease Sub-specialty Committee of the Dermatologist Branch of the Chinese Medical Doctor Association in 2016)" clinical diagnosis of bullous pemphigoid (requires histopathology) Supported by examination, direct immunofluorescence and pemphigoid antibody results); 3. Severity grade: graded according to the affected area of the body surface as mild (<10%) or moderate (10-50%); 4. Local single topical drug treatment and systemic use of hormones or immunosuppressive agents are not effective, and the symptoms are persistent or repeated; 5. Before the start of the study, fully listen to the explanation of the purpose and content of the experiment, and voluntarily sign a written consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with tumor or immunodeficiency disease; 2. Combined with other autoimmune diseases; 3. Combined with other serious system diseases; 4. Women during pregnancy or lactation; 5. Patients who have used immunosuppressive agents (except glucocorticoids) in the past 4 weeks; 6. Patients who have been treated with glucocorticoids continuously in the past 2 weeks and the dose has reached or exceeded 0.5mg/kg/d; 7. Patients who have used other biological agents (such as rituximab, omalizumab, etc.) in the past 4 weeks; 8. There are other situations that the researcher thinks should not be included in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin lesion area involvement score;The proportion of pruritus NRS severity score decreased from baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral blood eosinophil level;Total IgE level;BP180 and BP230 antibody levels; | — |
Countries
China
Contacts
Public ContactGang Wang
Xijing Hospital
Outcome results
None listed