PCSK9 inhibitor aliciumab in the treatment of hypercholesterolemia with carotid atherosclerosis
Conditions
Interventions
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-89 years; 2. The diagnostic standard of patients with dyslipidemia is higher than the blood lipid level stratification standard and the target value determined by the risk stratification of dyslipidemia in the Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults (2016 Revision), that is, TC = 5.2mmol/L and/or LDL-C = 3.4mmol/L; 3. Carotid atherosclerotic plaque formation was confirmed by carotid artery Doppler ultrasound; 4. The patients who voluntarily participate, are hospitalized and have conditional follow-up shall sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Secondary hyperlipidemia caused by thyroid dysfunction, nephrotic syndrome and familial hyperlipidemia; 2. Serious cardiac insufficiency: left ventricular ejection fraction (EF) = 30%; 3. Pregnant women; 4. Liver function is abnormal, and AST and ALT are 3 times or more higher than the upper limit of normal reference; 5. Those with connective tissue disease, rheumatic immune system disease, rhabdomyolysis, blood system disease and malignant tumor, and those with other types of intracranial lesions; 6. Have a history of major surgery and trauma, and suffer from acute and chronic infection and fever within one month; 7. Those who took statins and ezetimibe one month before admission, and those who had clear contraindications to the two drugs or had a history of allergy; 8. There is renal insufficiency, and the creatinine (Scr) is higher than the normal reference value.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Indexes of liver and kidney function;Creatine kinase;Blood lipid indicators;Hematological indicators; | — |
Countries
China
Contacts
Public ContactXu Yunhong
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed