Analgesia and sedation
Conditions
Interventions
Remazolam benzenesulfonate group:Rimazolam was induced under general anesthesia at 4-12mg/kg/h and maintained at 0.7mg/kg/h
The propofol group:Propofol was induced at 2.0-2.5mg/kg and maintained at 4-10mg/kg/h
Sponsors
People's Hospital of Ningxia Hui Autonomous region
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. 60 years old <= Age <= 80 years old, gender is not limited, nationality is not limited; 2. Elective surgery under general anesthesia, expected to be 2 hours <= operation time <= 4 hours; 3. Agree to participate in this study and sign an informed consent form; 4. ASA level I-III.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this researcher; 2. Preoperative schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis; 3. Unable to communicate because of coma, severe dementia, language disorder, end-stage disease, etc. 4. Cerebral infarction, cerebral hemorrhage, craniocerebral surgery, craniocerebral trauma; 5. Combined anesthesia (general anesthesia combined with other anesthetic methods, general anesthesia + intraspinal anesthesia, general anesthesia + regional nerve block, general anesthesia + incision block); 6. Inhalation anesthesia; 7. Critical condition (preoperative ASA grade >= IV); severe renal function damage (requiring renal replacement therapy); severe liver function damage (Child-Pugh grade C); 8. The attending physician or researcher believes that there are other situations that are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Agitation during awakening;Postoperative delirium;OAA/S scale;PACU scale;NRS scale;VAS scale;Postoperative incidence;Bispectral index;Blood pressure;Heart Rate;breathe;degree of blood oxygen saturation; | — |
Countries
China
Contacts
Public ContactQingshan Ye
Department of Anesthesiology, people's Hospital of Ningxia Hui Autonomous region
Outcome results
None listed