aortic valve disease
Conditions
Interventions
Mini-sternotomy group:Mini-sternotomy
Mini-thoracotomy group:Mini-thoracotomy
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the surgical indications recommended by the guidelines and need to perform elective aortic valve replacement; 2. Adults, 18-80 years old; 3. Sinus rhythm; 4. First cardiac surgery; 5. The subjects agreed to participate in the trial and agreed to the postoperative follow-up plan.
Exclusion criteria
Exclusion criteria: 1. The operation plan was changed during the operation, and the minimally invasive aortic valve replacement was converted to conventional sternotomy; 2. Other operations are combined at the same time, such as other valve operations, coronary bypass surgery, aortic surgery, etc; 3. Patients with endocarditis; 4. Patients with immune diseases, including Takayasu arteritis and Behcet's disease; 5. Patients with Marfan syndrome or other known connective tissue diseases; 6. Those with unstable circulation, such as low cardiac output, vasopressor dependence or need mechanical hemodynamic support; 7. Patients with obstructive hypertrophic cardiomyopathy; 8. Patients with liver and kidney dysfunction; 9. Patients with severe neurocognitive impairment (those who can't give informed consent, can't take care of themselves, and can't complete the follow-up plan after surgery); 10. Those who do not agree with the operation plan and those who quit midway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| level of IL-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major adverse cardiac events;rate of rehospitalization;EQ-5D-5L Score;SF-36 score; | — |
Countries
China
Contacts
Public ContactJi Qiang
Zhongshan Hospital affiliated to Fudan University
Outcome results
None listed