Mechanism of rTMS combined with EMG-driven neuromuscular electrical stimulation robotic training to promote functional reconstruction of upper limbs in stroke patients

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200058350

Enrollment

Unknown

Registered

2022-04-07

Start date

2022-04-11

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

Control group:Pseudo-stimulus +EMG driven multi-joint NMES- Robot training

Experimental group:rTMS combined with EMG - driven NMES- robot training

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-75 years; 2. Patients with unilateral cerebral apoplexy who met the diagnostic criteria in the Diagnostic Essentials of Various Cerebrovascular Diseases (1996) revised by the Fourth National Conference on Cerebrovascular Diseases were all confirmed by head CT or MRI scanning; 3. The course of the disease was more than 3 months of convalescence; 4. No visual or cognitive impairment, and can be trained according to the instructions; 5. The motion range of wrist joint is 45-60 degree, and the motion range of elbow joint is 30-180 degree; 6. MAS spasm score of elbow, wrist and finger is less than 3 points; 7. FMA score of upper limb function assessment was moderate to severe; 8. The target muscle of the upper limb has detectable EMG signal (greater than 3 standard deviation of the base value); 9. The MMSE of cognitive function assessment was more than 21 points.

Exclusion criteria

Exclusion criteria: 1. Dysfunction of vital organs such as heart, lung, liver and kidney, and unstable vital signs; 2. Pregnancy; 3. Patients with epileptic seizures; 4. The affected limb is in obvious pain and cannot be trained; 5. Severe aphasia; 6. There are metal implants in the skull and the skull is incomplete; 7. Implant a pacemaker.

Design outcomes

Primary

Measure	Time frame
Repetitive transcranial magnetic stimulation, rTMS;B-mode ultrasound measurement;Electrical impedance myography, EIM;	—

Secondary

Measure	Time frame
Action Research Arm Test, ARAT;Fugl-Meyer Assessment of Physical Performance;Modified Ashworth Scale, MAS;	—

Countries

China

Contacts

Public ContactHu Huijing

Institute of Medical Research of Northwestern Polytechnical University

huhuijing@nwpu.edu.cn+86 13632182641

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026