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Effect of sedation regimen based on intracranial pressure monitoring on sedation effectiveness and brain function in patients with acute craniocerebral injury

Effect of sedation regimen based on intracranial pressure monitoring on sedation effectiveness and brain function in patients with acute craniocerebral injury -- a single center, randomized and controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200058345
Enrollment
Unknown
Registered
2022-04-07
Start date
2022-05-01
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute craniocerebral injury

Interventions

Midazolam group:Midazolam
Remazolam toluenesulfonate group:Rimazole toluenesulfonate

Sponsors

Wuhan University, Zhongnan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with acute craniocerebral injury are expected to be ventilated for more than 48 hours and need sedation.

Exclusion criteria

Exclusion criteria: 1. Patients unable to undergo ultrasound due to eye injury or other factors; 2. Patients whose vital signs are extremely unstable or need high dose of vasoactive drugs for maintenance; 3. Patients with sinus bradycardia or atrioventricular block caused by heart rate 30kg/m^2; 10. Pregnant or lactating patients; 11. Patients participate in another clinical trial at the same time; 12. The investigator considered that the patient was not suitable to participate in the clinical study.

Design outcomes

Primary

MeasureTime frame
Duration of sedation compliance;—

Countries

China

Contacts

Public ContactWang Jing

Wuhan University, Zhongnan Hospital

wangjing9279@163.com+86 13100622008

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026