Evaluation of the predictive efficacy of the vasoactivity-positive inotropic drug score for the timing of hydrocortisone treatment for septic shock in term infants

A randomized controlled study of vasoactive inotropic score (VIS) for predicting the initiation of hydrocortisone therapy for term septic shock

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200058331

Enrollment

Unknown

Registered

2022-04-06

Start date

2022-04-30

Completion date

Unknown

Last updated

2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neonatal shock

Interventions

Group 1:Shock was treated with a vasoactive drug score of 59 without hydrocortisone

Group 2:Shock was treated with a vasoactive drug score of 59 and hydrocortisone

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Gestational age >=37 weeks; 2. Admitted to the neonatal intensive ward within 24 hours of the onset of septic shock; 3. Fluid resuscitation and vasoactive medication did not correct the shock, VIS>=59.

Exclusion criteria

Exclusion criteria: 1. Congenital cardiovascular dysplasia affecting hemodynamics. 2. Genetic metabolic diseases, etc.

Design outcomes

Primary

Measure	Time frame
The reversal time of shock;Mortality;Complications;	—

Secondary

Measure	Time frame
The duration of ventilatory support;Enteral nutrition time;The hospital days and medical cost;	—

Countries

China

Contacts

Public ContactYe Xiuzhen

yxzh328@126.com+86 13725116591

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026