diabetic foot
Conditions
Interventions
Control group:None
Pentoxifylline group:Give pentoxifylline
Cilotazole group:Give Cilotazole
Sponsors
Chu Hsien-I Memorial Hospital, Tianjin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Diabetic foot patients; 2. Severe lower extremity ischemia (ABI<0.5, TcPO2< 20mmHg, or lower extremity ultrasound /CTA report severe stenosis (over 75%) or occlusion of lower extremity arteries; 3. Aged over 18 years.
Exclusion criteria
Exclusion criteria: 1. Acute stage of myocardial infarction and heart failure; 2. Acute stage of stroke; 3. Patients with severe renal insufficiency or dialysis; 4. Liver insufficiency (ALT>100 U); 5. Severe infection that cannot be controlled; 6. Patients who could not undergo endovascular therapy or failed endovascular therapy of lower limbs; 7. Patients unwilling to attend or unable to complete follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| patency of artery in lower extremity;maintaining time of patency of artery in lower extremity; healing rate of foot wound;healing time of foot wound;recurrent rate of foot wound one year later; | — |
Secondary
| Measure | Time frame |
|---|---|
| amputation rate;all-cause mortality;cardiovascular and cerebrovascular event;security(adverse reaction); | — |
Countries
China
Contacts
Public ContactXu Jun
Chu Hsien-I Memorial Hospital, Tianjin Medical University
Outcome results
None listed