abortion
Conditions
Interventions
Group A:Low-dose esketamine
Group B:Medium-dose esketamine
Group C:High-dose esketamine
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-45 years, BMI 18-28 kg/m^2, ASA I or ?; 2. Clearly understand and voluntarily participate in the study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous vaginal delivery; 2. Hearing impairment, unable to cooperate with respondents to complete the questionnaire; 3. Patients with significant respiratory dysfunction before surgery (obstructive sleep apnea syndrome, acute respiratory tract infection, acute onset of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 4. Patients with circulation dysfunction before surgery (Unstable angina pectoris; Myocardial infarction occurred within 6 months before screening; Resting ECG heart rate =450ms, female >=470ms); 5. Anemia or thrombocytopenia: Hb < 90g/L, PLT < 80x10^9/L; 6. Patients with mental diseases (schizophrenia, mania, bipolar disorder, mental disorder, etc.), long-term use of psychotropic drugs and cognitive dysfunction; 7. Patients suffering from infectious diseases (hepatitis B, tuberculosis, HIV, syphilis, etc.); 8. Patients who take opioids every day for 1 month or intermittently for nearly 3 months, and are allergic or contraindicated to research drugs, opioids, propofol and other drugs and their components; 9. Patients judged to have difficulties in respiratory tract management: modified Martenberg score ? or above; 10. Patients participating in other clinical trials; 11. The investigator considered the patients unfit to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Low blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative hemodynamics;Time indicator; | — |
Countries
China
Contacts
Public ContactChen Jiejuan
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed