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The effect of low-dose postoperative dexmedetomidine infusion on incidence of delirium and clinical prognosis in elderly patients with acute myocardial infarction who underwent primary percutaneous coronary intervention in CCU: a single center, prospective,randomized, open label, pilot study

The effect of low-dose postoperative dexmedetomidine infusion on incidence of delirium and clinical prognosis in elderly patients with acute myocardial infarction who underwent primary percutaneous coronary intervention in CCU: a single center, prospective,randomized, open label, pilot study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200058272
Enrollment
Unknown
Registered
2022-04-04
Start date
2022-04-10
Completion date
Unknown
Last updated
2023-12-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocardial Infarction

Interventions

Experimental group:dexmedetomidine
Control group:none

Sponsors

The Second Affiliated Hospital of Harbin Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients with acute myocardial infarction (AMI) aged >=65 years; 2. Onset time <=24h; 3. Receive PCI treatment; 4. Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Ventricular fibrillation, cardiogenic shock, Killip ?-IV; 2. Postoperative systolic blood pressure continued to 240ms or degree II-III atrioventricular block; 4. Severe postoperative dyspnea, blood oxygen saturation <92%; 5. Disturbance of consciousness or previous severe cerebrovascular disease; 6. Known severe liver and kidney dysfunction; 7. Known allergy to dexmedetomidine; 8. Pregnant and lactating patients; 9. Malignant tumor or expected survival <1 year; 10. The investigator judged that the subjects had poor compliance and could not complete the study as required; 11. Participate in other randomized controlled studies.

Design outcomes

Primary

MeasureTime frame
delirium;

Secondary

MeasureTime frame
mortality;left ventricular ejection fraction;

Countries

China

Contacts

Public ContactTan Jinfeng

The Second Affiliated Hospital of Harbin Medical University

418904005@qq.com+86 13633643383

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026