Degeneration of the spine
Conditions
Interventions
Control group:
Intervertebral disc degeneration with Modic change group:
Intervertebral disc degeneration without Modic change group:
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The patient agreed to participate in the study, voluntarily participated in the study and signed the informed consent; 2. X-ray and MRI confirmed disc degeneration with or without Modic change; 3. Age above 18 years, gender unlimited; 4. Able to communicate well with researchers and follow the whole validation requirements.
Exclusion criteria
Exclusion criteria: 1. Previous acute or severe infection; 2. Patients with metabolic disorder, immune dysfunction and implant abuse; 3. Malignant tumor; 4. Patients don't want to participate; 5. History of spinal surgery or minimally invasive treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Oswestry Disability Index score for lumbar and leg pain;Visual Analogue Scale score for lumbar and leg pain;Degree of intervertebral disc degeneration;Parting of Modic change;Gut microbiota metabolites;Gut secretions or hormones;Inflammatory factor;Diversity analysis of gut microbiota; | — |
Countries
China
Contacts
Public ContactJiayu Chen
The First People's Hospital of Yunnan Province
Outcome results
None listed