Spine Surgery
Conditions
Interventions
Group R:Ropivacaine for retrolaminar block
Group E:Mixture of Esketamine and ropivacaine for retrolaminar block
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Elective posterior Lumbar Interbody Fusion; 2. Age 18-65; 3. American Society of Anesthesiologists (ASA) Grade I-II; 4. Obtain the consent of the patient's family members before the operation, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Contraindications of nerve block: local anesthetic allergy, coagulation disorder, puncture site damage, infection ; 2. Severe heart disease, liver insufficiency (Child-Pugh grade C) or renal insufficiency (serum creatinine > 442 umol/L or those requiring renal replacement therapy), ASA grade >= grade III or morbidly obese (BMI>30kg/m2); 3. Chronic opioid addiction or use of other analgesic drugs for more than 3 months; 4. Inability to communicate due to severe dementia, language impairment, or end-stage disease; 5. Those who refused to participate in this study, refused to use PCIA, and sign informed consent; 6. Contraindications related to esketamine Allergic to esketamine; Patients at serious risk of elevated blood pressure or intracranial pressure; Poorly controlled or untreated patients with hypertension (resting systolic/diastolic blood pressure exceeding 180/100 mmHg); Preeclampsia and eclampsia; Untreated or undertreated patients with hyperthyroidism (hyperthyroidism)Patients with mental disorders, major depression, schizophrenia or dementia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative NRS score at rest and active movement; | — |
Secondary
| Measure | Time frame |
|---|---|
| consumption of propofol and remifentanil during surgery;First press time and total press times of postoperative analgesia pump;Postoperative sufentanil consumption;Postoperative recovery quality;Adverse reactions such as nausea, vomiting, arrhythmias, hallucinations, delirium; | — |
Countries
China
Contacts
Public ContactWang Yingbin
Lanzhou University Second Hospital
Outcome results
None listed