Septic Shock
Conditions
Interventions
S(+)-ketamine group:Analgesia by S(+)-ketamine in 72H after admission
Remifentanil group:Analgesia by remifentanil in 72H after admission
Sponsors
Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age: >= 18 years old; 2. Patients diagnosis of septic shock: comply with the criteria of septic shock developed by SCCM/ESICM in 2016; 3. Patients with invasive mechanical ventilation, and the time is expected to more than 72 h; 4. Family members signed informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of mental illness or cerebrovascular accident (cerebral hemorrhage or cerebral infarction) or brain injury during three months(including this time); 2. Pregnant women; 3. Contraindicate to S(+)-ketamine as the following: (1) Allergic to S(+)-ketamine and its accessories; (2) Confirmed but uncontrolled coronary heart disease; (3) Poorly controlled or uncontrolled hypertension (systolic/diastolic blood pressure more than 180/100 mmHg at rest); (4) Preeclampsia and eclampsia; (5) No treatment or inadequate treatment in patients with hyperthyroidism; (6) Aneurysm(rupture risk when hypertension); (7) Ophthalmologic operation(risk of elevated intraocular pressure); (8) Need of hysteranesis(uterine torn, uterine rupture, umbilical cord prolapse,etc); 4. Allergic to propofol and hyperlipidemia pancreatitis (triglycerides>11.3mmol/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dose of norepinephrine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of sedative and analgesics;Hemodynamic parameters;Mechanical ventilation time;ICU length of stay;Incidence of abnormal electroencephalogram;Cognitive function;Prognosis;Function of organs; | — |
Countries
China
Contacts
Public ContactLijun Liu
Second Affiliated Hospital of Soochow University
Outcome results
None listed