COVID-19
Conditions
Interventions
FZJDG:Conventional therapy+FZJDG,1 bag (15g) each time, 3 times a day
Control group:Conventional therapy
Sponsors
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Confirmed Covid-19 patients according to Scheme for Diagnosis and Treatment of 2019 Novel Coronavirus Pneumonia(The 8th Trial Edition); 2. Age>=18 years old; 3. Adults who have at least one following characteristic associated with a high risk of progression to severe Covid-19: (1) >60 years old; (2) People with underlying diseases such as cardiovascular disease (including hypertension), chronic lung disease, diabetes mellitus, chronic liver and kidney disease, tumors; (3) Immune deficiency (e.g. AIDS patients, long-term use of corticosteroids or other immunosuppressive drugs leading to a hypoimmune state); (4) Obesity (BMI>=30); (5) Women in late pregnancy and perinatal period; (6) Heavy smokers. Or emerging warning indicators of progression to severe/critical disease: (1) Hypoxemia or progressive worsening of respiratory distress; (2) Decrease of tissue oxygenation indicators (e.g. finger oxygen saturation, oxygenation index) or progressive elevation of lactate; (3) Progressive decrease in peripheral blood lymphocyte count or progressive increase in inflammatory factors such as interleukin 6, CRP, ferritin, etc.; (4) Marked elevation of coagulation-related indicators such as D-dimer; (5) Marked progression of lung lesions on chest imaging. 4. Those who agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Already progressed to heavy/critical Covid-19 prior to enrollment; 2. Allergic or allergic to known herbal medicines; 3. Unwilling to take herbal medicines; 4. Those previously infected with SARS-CoV-2; 5. Assessed by a physician to be unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients who progressed to a severe disease status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Shortness of breath with a respiratory rate (RR) =30/min and peripheral blood oxygen saturation =93% in resting state;The proportion of tracheotomy, intubation, and invasive mechanical ventilation;Incidence of complications.;Proportion of ICU admissions;Length of hospital stay;Concomitant symptoms when discharge;Morbidity rate;The proportion of high-flow nasal-catheter oxygenation (HFNC) and Noninvasive Mechanical Ventilation;Time to symptom recovery; | — |
Countries
China
Contacts
Public ContactZhongde Zhang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed