Stroke
Conditions
Interventions
High-frequency rTMS group:rTMS
Low-frequency rTMS group:rTMS
sham rTMS group:rTMS
Sponsors
The First Affiliated Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The first onset was diagnosed as stroke when enrolled, and the focus was located under the cortex of the blood supply area of unilateral middle cerebral artery; 2. Age: 35-80 years; 3. The course of disease ranged from 2 weeks to 3 months; 4. Fugl Meyer score of upper limb was less than 60; 5. Good cognitive function, able to cooperate with examination and treatment.
Exclusion criteria
Exclusion criteria: 1. Recurrent stroke and other brain diseases; 2. Drug dependence or mental illness; 3. Contraindications of MRI or transcranial magnetic stimulation (such as cardiac pacemaker, intracranial implant, implanted drug pump, history of epilepsy); 4. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl Meyer score of upper extrimity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Action research arm test, ARAT;Wolf motor function test, WMFT;Barthel index, BI;Surface electromyogram;Motor evoked potential;Somatosensory evoked potentials;Resting-state functional MRI;3D T1 MRI;Diffusion tensor imaging, DTI; | — |
Countries
China
Contacts
Public ContactDai Zhang
The First Affiliated Hospital of China Medical University
Outcome results
None listed