Heart Failure Dilated Cardiomyopathy
Conditions
Interventions
Simplified Treatment Group:Simplified Treatment
Sponsors
Fuwai Hospital, CAMS & PUMC
Eligibility
Sex/Gender
All
Age
No minimum to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 50mm (female) or >55mm (male); NT-proBNP > 300 pg/ml; 4. Patients are taking three or more standard medications, which include: Angiotensin converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB)/ Angiotensin II Receptor Blocker Neprilysin Inhibitor (ARNI), beta-receptor blocker, mineralocorticoid receptor antagonist (MRA), diuretic, etc. Treatment is determined according to clinical conditions; 5. Heart failure recovery, with all the following conditions were met: (1) absence of signs and symptoms of heart failure; (2) LVEF>50%, and LVEDD=20 ml/kg/min; 6. Has provided informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients have the following cardiovascular diseases: familial dilated cardiomyopathy, valvular heart disease, coronary heart disease, other cardiomyopathies, pulmonary vascular disease, congenital heart disease, other heart diseases requiring surgical interventions, uncorrected arrhythmia, indicated for or has been treated with ICD/CRT/CRTD; 2. Patients with uncontrolled blood pressure >140/90mmHg; Diuretics and/or aldosterone receptor antagonists should be taken by the patients; 3. Uncontrolled rapid supraventricular/ventricular arrhythmias such as atrial flutter, atrial fibrillation, atrial tachycardia, ventricular tachycardia etc; 4. Patients are complicated by other diseases that need diuretics and aldosterone receptor antagonist treatment; 5. Estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2; 6. Complicated with other systemic diseases that require repeated hospitalization and influence survival, such as malignancies with short life expectancy, autoimmune diseases, infectious diseases, hematological diseases, thrombotic diseases (DVT, pulmonary embolism), cerebrovascular diseases (stroke, hemorrhage, aneurysm), etc; 7. Patients refuse to have blood samples taken and could not comply with clinical follow-up; 8. Patients have poor compliance, such as being unable to adhere to medications or abstaining from susceptible factors, such as alcohol, or pregnancy; 9. Patients have other conditions that are not suitable for this study, judged by the clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of maintaining cardiac recovery status within 1 year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart failure rehospitalization within 1 year;Quality of life score;Cardiopulmonary exercise test peakVO2;Cardiovascular mortality within 1 year;All-cause mortality within 1 year; | — |
Countries
China
Contacts
Public ContactYunhong Wang
Fuwai Hospital, CAMS & PUMC
Outcome results
None listed