non-obstructive azoospermia
Conditions
Interventions
Letrozole group:Letrozole+Vc+Ve+CoQ10
Spermidine group:Spermidine+Vc+Ve+CoQ10
Letrozole+Spermidine group:Letrozole+Spermidine+Vc+Ve+CoQ10
Control group:Vc+Ve+CoQ10
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1 Age 18-45 years old; 2 NOA patients with Klinefelter syndrome, mumps orchitis, deletion of Y chromosome c region, history of cryptorchidism; 3 Voluntary participation in this clinical study, subjects signed a written informed consent before the start of the study.
Exclusion criteria
Exclusion criteria: 1 Hypogonadotropic hypogonadism; 2 Azoospermia caused by vas deferens obstruction factors, such as epididymal obstruction caused by epididymitis, congenital absence of vas deferens, ejaculatory duct obstruction; 3 With urogenital infection; 4 Received AI, hCG, hMG, estrogen receptor antagonists and other drugs that affect the hypothalamic-pituitary-gonadal axis within 4 weeks; 5 Inoperable due to various reasons, such as coagulation dysfunction; 6 There are systemic diseases, such as hypertension, diabetes, liver insufficiency, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of sperm retrieval; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sperm concentration;Sperm motility;Microscopic sperm retrieval rate;Pregnancy Rate; | — |
Countries
China
Contacts
Public ContactLi Zheng
Shanghai General Hospital
Outcome results
None listed