pancreatic cancer
Conditions
Interventions
one:NA
Sponsors
Second People's Hospital of Anhui Province
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age: = 18 years old, male or female; 2. Patients with stage III (inoperable), IV (metastatic) or postoperative recurrent pancreatic cancer (ductal adenocarcinoma) confirmed by pathology or histology; 3. The patient has not received standard systematic treatment in the past; 4. At least one measurable lesion (spiral CT scanning = 10mm, meeting RECIST 1.1 standard); 5. ECOG score: 0-2; 6. Expected life = 3 months; 7. If the main organs function normally, they meet the following standards: 1) The blood routine examination standard should meet (no blood transfusion and blood products within 14 days): a.HB=90 g/L b.ANC=1.5 × 109/L c.PLT=80 × 109/L 2) Biochemical examination shall meet the following standards: a.TBIL45 ml/min (Cockcroft Gault formula); 8. Subjects volunteered to join the study and signed an informed consent form, with good compliance and cooperation in follow-up.
Exclusion criteria
Exclusion criteria: 1. Patients with central nervous system metastasis; 2. There are uncontrollable pleural effusion, pericardial effusion or ascites that need drainage; 3. Had a history of allergy to monoclonal antibody, carrelizumab, paclitaxel (albumin binding type), apatinib and Fuzi Lizhong Pill; 4. Received any investigational drug within 4 weeks prior to the first use of the investigational drug; 5. A history of active autoimmune diseases or autoimmune diseases; 6. Patients with severe and uncontrollable infection; 7. Pregnant or lactating women; 8. Known hereditary or acquired bleeding and thrombotic tendencies (such as hemophiliacs, coagglutinopathy, thrombocytopenia (PLT < 80×109/L), etc.); 9.Other conditions that the investigator did not consider fit for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;progression free survival;Disease control rate; | — |
Countries
China
Contacts
Public ContactZhanggui Wang
Second People's Hospital of Anhui Province
Outcome results
None listed