Postoperative cognitive impairment
Conditions
Interventions
Propofol group (group P):Only propofol was used for anesthesia maintenance except remifentanil and cisatracurium besylate
Propofol and sevoflurane group (PS group):In addition to remifentanil and cisatracurium, propofol and sevoflurane were used for anesthesia maintenance
Propofol, sevoflurane and dexmedetomidine group (PSD group):Propofol, sevoflurane and dexmedetomidine were used for anesthesia maintenance except remifentanil and cisatracurium besylate
Control group:None
Sponsors
Department of Anesthesiology, the First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65-80 years; 2. No history of chemoradiotherapy; 3. ASA grade I-III; 4. Patients with pulmonary operation requiring single lung ventilation during the operation. The control group only had to meet the first three inclusion criteria, and the experimental group had to meet all inclusion criteria.
Exclusion criteria
Exclusion criteria: 1. Patients with schizophrenia, epilepsy, Parkinson's disease and myasthenia gravis; 2. Patients with communication difficulties due to coma, severe dementia, language disorder, or unable to cooperate due to other diseases; 3. Patients with craniocerebral trauma or other craniocerebral diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function questionnaire score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral oxygen saturation value; | — |
Countries
China
Contacts
Public ContactWei Xin
Department of Anesthesiology, the First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed