Diabetic Polyneuropathy (DPN)
Conditions
Interventions
Gold Standard:All patients with diabetes underwent nerve conduction function tests (NCS) to assess neuropathy and were divided into two groups based on NCS results
Index test:Routine ultrasound (US) and elastic shear wave imaging (SWE) were performed on the tibial nerve and common peroneal nerve of both lower limbs in all patients with diabetes
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria of healthy volunteers: (1) Aged >18 years; (2) Cooperate with B ultrasound examination. 2. Inclusion criteria for ordinary diabetic patients: diabetes diagnosis is mainly based on WHO diabetes diagnosis criteria in 1999, that is, meeting one of the following three criteria plus diabetes symptoms (such as typical three more and one less’’ symptoms) : (1) Random blood glucose > 11.1mmol/L; (2) Fasting blood glucose > 7.0mmol/L; (3) OGTT 2-hour blood glucose (glucose tolerance test was greater than 11.1mmol/L. If the tested person has no obvious symptoms of diabetes, the diagnosis needs to be verified on another day. 3. Inclusion criteria for diabetic peripheral neuropathy patients: DPN patients are diagnosed according to positive NCS results and positive signs or symptoms of neuropathy. (1) Patients with negative NCS results and negative signs and symptoms are considered DPN-free. The clinical criteria for DPN require the presence of more than one symptom (numbness, tingling, weakness, foot pain, and ataxia) or signs consistent with a pattern of distal symmetrical neuropathy (abnormal knee or ankle reflexia and temperature, light contact, monfilaments, or vibrations); (2) Positive NCS and positive clinical symptoms or signs were included in DPN group; otherwise, it was diagnosed as possible DPN and excluded. Patients with negative NCS and negative clinical signs or symptoms were included in the non-DPN group.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for healthy volunteers: (1) Diabetes mellitus; (2) A known history of other causes of polyneuropathy, such as genetics; (3) Alcohol, metabolism, cervical and lumbar lesions or toxic factors; (4) Skin lesions or swelling that interfere with nerve conduction; (5) History of cerebral infarction and other central nervous system; (6) Known leg or ankle fractures or surgical history. 2. Exclusion criteria for common diabetic patients: (1) Type 1 diabetes; (2) A known history of other causes of polyneuropathy, such as genetics; (3) Alcohol, metabolism, cervical and lumbar lesions or toxic factors; (4) Skin lesions or swelling that interfere with nerve conduction; (5) History of cerebral infarction and other central nervous system; (6) Known leg or ankle fractures or surgical history. 3. Excluded diagnosis of diabetic peripheral neuropathy: (1) Type 1 diabetes; (2) A known history of other causes of polyneuropathy, such as genetics; (3) Alcohol, metabolism, cervical and lumbar lesions or toxic factors; (4) Skin lesions or swelling that interfere with nerve conduction; (5) History of cerebral infarction and other central nervous system; (6) Known leg or ankle fractures or surgical history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Young's modulus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cross-sectional area;The perimeter;Diameter before and after; | — |
Countries
China
Contacts
Public ContactWei Zairong
Outcome results
None listed