None listed
Conditions
Interventions
K1 group:0.15mg/kg esketamine was given before induction
S group:normal saline was given before induction
Sponsors
Mindong Hospital, Ningde
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged > 60 years, ASA II-III, BMI<=25 kg/m^2, who underwent electronic bronchoscopy under general anesthesia; 2. In accordance with the Guidelines for the Application of Diagnostic Bendable Bronchoscopy in Adults (2019 Edition) of the Respiratory Society of the Chinese Medical Association, there are no contraindications; 3. No auditory, visual or intellectual impairment, no other conditions that may cause difficulty in assessing the degree of postoperative recovery, able to understand the basic principles of the experiment, and have signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Suffering from mental or neurological diseases (schizophrenia, Alzheimer's, etc.); 2. Increased intraocular pressure or intracranial pressure, such as glaucoma, acute eye injury; 3. Electrolyte metabolism disorder existed before surgery, such as K+=5.5mmol/L; 4. Severe liver dysfunction, defined as ALT, AST, GGT and other related indicators >= 1.5 times the normal value; 5. Untreated or undertreated patients with hyperthyroidism and pheochromocytoma; 6. Severe cardiovascular and cerebrovascular diseases, such as unstable angina pectoris or myocardial infarction within the past six months, previous severe angina attacks, congestive heart failure, or high-risk coronary artery disease; Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure of more than 180/100 MMHG), hypertension grade >=2 during hospitalization (systolic blood pressure of 160 to 179mmHg, diastolic blood pressure of 100 to 109mmHg) or risk stratification of hypertension >= high risk, etc.; 7. Patient who are unable to breathe through the nose for various reasons; 8. Mallampati grade >=3 or combined with obstructive sleep apnea hypopnea syndrome; 9. Patients with contraindications in the use of nasopharyngeal snorkel; 10. Patients with contraindications of non-invasive arterial blood pressure monitoring; 11. Patients with a long history of alcohol abuse or abuse of the drugs in the test; 12. Allergic to the active ingredient or related excipients of the drug used in the study; 13. Participated in other clinical trials within the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of hypoventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| mean arterial pressure;heart rate;cough score;Vigilance/Sedation Observation Score (OAA/S Score);intraoperative drug consumption;satisfaction; | — |
Countries
China
Contacts
Public ContactWeng Digui
Outcome results
None listed