A prospective, randomized, controlled study of preoperative oral melatonin to reduce the incidence of postoperative delirium in elderly spinal surgery patients

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200058039

Enrollment

Unknown

Registered

2022-03-27

Start date

2022-03-25

Completion date

Unknown

Last updated

2023-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

The sleep disorder group and the non-sleep disorder group:Subjects were randomly assigned melatonin or placebo 3 days before surgery and instructed to take it at bedtime for 3 consecutive nights.

Eligibility

Sex/Gender

All

Age

65 Years to 100 Years

Inclusion criteria

Inclusion criteria: From January 1, 2022 to December 31, 2022, 200 elderly patients (=65 years old) undergoing spinal surgery under general anesthesia in Ningbo Sixth Hospital (calculated based on sample size) were classified as American Society of Anesthesiologists (ASA) grade ? to ?, male and female. All participants signed informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: (1) refused to participate in the investigator; (2) patients with audiovisual impairment who were unable to complete the preoperative evaluation; (3) patients with preoperative mental disorders or a personal history of psychosis.

Countries

China

Contacts

Public ContactLiyong Yuan

yuanliyong1973@163.com18967109033

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026