Uremia, itchy skin
Conditions
Interventions
Group 1:Sodium thiosulfate 1.92g intravenously, three times a week
Group 2:Sodium thiosulfate 3.2g intravenously, three times a week
Group 3:Sodium thiosulfate 4.48g intravenously, three times a week
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years, gender unlimited; 2. Stable dialysis for more than 3 months, dialysis frequency 2-3 times/week; 3. Cognitively and mentally normal, symptoms and efficacy can be evaluated; 4. Skin pruritus was the main symptom, and the itch VAS score was >=4 points; 5. Kt/v >=1.2; 6. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. There is a kidney transplant plan in the near future; 2. Unmanageable hypertension, SBP>=180mmHg and/or DBP>=110mmHg; 3. Severe liver insufficiency, glutamic-pyruvic transaminase more than 3 times the upper limit of normal value; 4. Patients with stroke within 3 months; 5. Patients with severe hyperphosphatemia and severe parathyroidism had blood phosphorus >=3.0mmol/L and PTH>=1000pg/ml; 6. Patients currently receiving radiotherapy and chemotherapy for malignant tumors; 7. Pregnant patients; 8. Patients with acute and chronic infection; 9. Patients with known allergy to sodium thiosulfate; 10. Those who are participating in other drug clinical trials or have participated in other clinical trials within 3 months; 11. Patients deemed unsuitable for this clinical study by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine;liver function;kidney function;electrolyte;parathyroid hormone;itching score; | — |
Countries
China
Contacts
Public ContactWang Niansong
Outcome results
None listed